Description
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA.
COMPANY OVERVIEW:
Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.
POSITION OVERVIEW:
Disc Medicine’s Drug Metabolism and Pharmacokinetics (DMPK) team is seeking an experienced scientist to support the application of pharmacokinetic (PK) and pharmacodynamic (PD) sciences in our drug discovery and development portfolios, with more focus on biologics programs.
As a key member of the cross‑functional teams, you will apply in vitro, in vivo, and modeling approaches to characterize the absorption, distribution, metabolism, excretion (ADME), and PK/PD properties of small molecules and biologics.
You will serve as a DMPK project representative and contribute across all stages of portfolio advancement, from early compound screening and optimization through IND‑enabling studies and regulatory submissions. Responsibilities include experimental design, data analysis and interpretation, human PK and efficacious dose projection, reporting, and strategic guidance.
This role requires regular interaction with internal and external partners to ensure timely, high‑quality delivery of ADME/PKPD data and to drive DMPK strategy for both Discovery and Development programs.
RESPONSIBILITIES:
- Serve as the DMPK representative on biologics and/or small molecule project teams, providing scientific and strategic leadership.
- Design, conduct, interpret, and report in vitro ADME, in vivo PK, and PK/PD studies.
- Develop and maintain compound selection criteria to support consistent decision‑making across projects.
- Partner effectively with modeling and simulation experts, toxicologists, and clinical pharmacologists for human PKPD prediction, toxicology and clinical study support.
- Summarize and present scientific results to project teams, leadership, and broader stakeholders.
- Oversee external CRO partners to ensure high‑quality data generation within budget and timelines.
- Contribute expert‑level guidance to regulatory submissions for biologics and/or small molecules.
REQUIREMENTS:
- MS in DMPK, biology, chemistry, or related field with 8+ years of relevant experience, or PhD (or equivalent) with 5+ years of relevant industry experience.
- Demonstrated expertise in large‑molecule PK, PKPD, and general discovery or development areas.
- Strong working knowledge of ADME, PK, PKPD for small molecules is an important plus.
- Proven ability to evaluate and apply innovative PK and PK/PD approaches to predict human PK, generate hypotheses, design studies, inform clinical plans, and support regulatory filings is highly preferred.
- Experience working effectively and collaboratively with cross‑disciplinary teams; ability to lead, influence, and contribute to decision‑
- Excellent written and verbal communication skills.
The annual base salary range for this position is listed below. Actual pay rates are determined by considering multiple factors including qualifications, relevance of experience, education & credentials, subject matter expertise, and internal parity.
Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment.
Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit their resume to be considered for current and future opportunities.
Disc Medicine respects your privacy. For information about how Disc processes your personal data in the context of your candidacy, please see our Privacy Notice.
Similar jobs
Est. 207,500 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 270,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 388,500 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 195,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 310,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 192,500 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 193,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 120,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 168,000 USD
Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. COMPANY OVERVIEW: Disc Medicine is a clinical-stage biopharmaceutical company committed to discove…
Est. 192,250 USD
What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner? About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-h…
Est. 127,500 USD
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA…
Est. 210,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 220,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 177,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 177,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 290,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 230,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 179,500 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 127,500 USD
Location: This position may be performed remotely with travel to the Boston area as needed, and an expected 20–30% travel to CDMO sites, particularly during validation campaigns, critical investigations, and health autho…
Est. 176,945 USD
Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, suppor…
Est. 259,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 157,000 USD
Location: This position may be performed remotely with travel to the Boston area as needed, and an expected 20–30% travel to CDMO sites, particularly during validation campaigns, critical investigations, and health autho…
Est. 204,209 USD
About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and i…
Est. 175,000 USD
Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity We’re seeking a Principal Scientist in Process Chemistry to lead drug substance activit…
Est. 178,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 207,000 USD
Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on…
Est. 197,920 USD
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clini…
Est. 94,000 USD
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA…
Est. 215,000 USD
Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nerv…
Est. 204,250 USD
What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner? About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-h…